Plinabulin’s MOA

Plinabulin’s MOA

Plinabulin is a GEF-H1 activator that destabilizes microtubule networks in the cell’s cytoskeleton and releases the guanine nucleotide exchange factor, GEF-H1. This process activates downstream signal transduction pathways, leading to dendritic cells, or DC, maturation, T cell activation and neutropenia prevention. Plinabulin is differentiated from other microtubule depolymerizing agents, such as the CA4P class, which cannot induce DC maturation or neutropenia prevention.

plinabulin-moa